A genetic study of the association of six polymorphisms with rheumatoid arthritis in the Egyptian population

Abstract Background Rheumatoid arthritis (RA) is an autoimmune disease in which the immune system attacks tissues of joints by mistake. Different factors—either genetic or environmental—affect development RA patients. A lot studies aimed to examine associations with this different populations. This research aspires perform a association study between six single-nucleotide polymorphisms (SNPs) and Egyptian population 49 controls 52 The SNPs that are included MIR146A rs2910164 (C:G), MIR499/MIR499A rs3746444 (T:C), MTMR3 rs12537(C:T), MIR155HG rs767649 (A:T), IRAK1 rs3027898 (A:C) PADI4 rs1748033 (C:T). Methods Real-time PCR TaqMan allelic discrimination assay were both used genotyping. Odds ratio models 95% confidence interval test associations. multiplicative, recessive, dominant co-dominant. Result demonstrated results indicated rs12537 associated RA, while showed no all tested models. remaining excluded as they didn't pass Hardy–Weinberg equilibrium test. Conclusion susceptibility RA. Moreover, had role disease.